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Related Experiment Video

Updated: Feb 7, 2026

Creation of Colonic Anastomosis in Mice

Creation of Colonic Anastomosis in Mice

Published on: January 17, 2019

Colon insufflation and visualization management using a novel rectal seal device.

Julia Ding^1,2,3, Nabil Shalabi^1,3, Colin Tracey³

¹Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.

Igie : Innovation, Investigation and Insights

|February 6, 2026

Summary

This summary is machine-generated.

Inadequate insufflation during colonoscopies is common. A new rectal seal device, RECSEAL, effectively manages gas leakage, improving colonic insufflation and visualization during procedures.

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Last Updated: Feb 7, 2026

Creation of Colonic Anastomosis in Mice

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Published on: January 17, 2019

The C-seal: A Biofragmentable Drain Protecting the Stapled Colorectal Anastomosis from Leakage

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Published on: November 4, 2010

Optimized Sealing Process and Real-Time Monitoring of Glass-to-Metal Seal Structures

Optimized Sealing Process and Real-Time Monitoring of Glass-to-Metal Seal Structures

Published on: September 2, 2019

Area of Science:

Gastroenterology
Medical Device Development
Endoscopy

Background:

Inadequate insufflation during colonoscopies, caused by gas leakage, impedes luminal visualization.
A survey of gastroenterologists revealed a 6.6% rate of inadequate insufflation requiring intervention.

Purpose of the Study:

To address inadequate insufflation in colonoscopies by developing a novel rectal seal device.
To evaluate the efficacy of the RECSEAL device in managing insufflation leakage and improving visualization.

Main Methods:

Development of the RECSEAL, a silicone rectal seal device designed for safe insertion and retention in the anal canal.
Evaluation of RECSEAL using pressure sensors in bench, ex vivo (simulated poor anal tone), and in vivo (pig models) settings.

Main Results:

The RECSEAL maintained significantly higher colonic pressures (32-33 mm Hg) compared to controls (0.3-3.6 mm Hg) in both intact and injured anal sphincter models (P < .0001).
The device demonstrated improved lumen visualization in collapsed colons.
Feasibility of RECSEAL was confirmed in an in vivo pig model.

Conclusions:

The flexible RECSEAL effectively increases luminal pressure in the colon.
RECSEAL shows potential to enhance colon insufflation and visualization during colonoscopies.