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Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
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Guy's Cancer Cohort: Guy's Cancer Centre's Real-World Evidence Programme 5 years later.

C L Moss1, B Russell1, G George1

  • 1King's College London, School of Cancer and Pharmaceutical Sciences, Transforming cancer OUtcomes through Research (TOUR), London, UK.

ESMO Real World Data and Digital Oncology
|February 6, 2026
PubMed
Summary
This summary is machine-generated.

The Guy's Cancer Cohort database enhances real-world evidence (RWE) for cancer research. This expanded database supports studies on cancer diagnosis, treatment, and patient outcomes, improving clinical decision-making.

Keywords:
cancerreal-world dataresearch databaseroutine clinical data

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Area of Science:

  • Oncology
  • Data Science
  • Epidemiology

Background:

  • The increasing burden of cancer necessitates robust real-world data (RWD) for research.
  • Guy's Cancer Real-World Evidence Programme, established in 2018 at Guy's and St Thomas' Trust (GSTT), leverages RWD to inform clinical decision-making and local policy.
  • The Guy's Cancer Cohort (GCC) database, a key component of this program, has been instrumental in advancing real-world evidence (RWE) capabilities and data integration.

Purpose of the Study:

  • To describe the Guy's Cancer Cohort (GCC) database, its renewal, and expansion.
  • To highlight the GCC's role in facilitating clinical, mechanistic, and supportive care research.
  • To emphasize the database's contribution to improving patient care and outcomes through enhanced data collection and linkage.

Main Methods:

  • The GCC database includes pseudonymised data from patients investigated, diagnosed, and/or treated for cancer.
  • Data capture encompasses demographics, tumour characteristics, treatments, quality of life, and imaging data.
  • The database adheres to the National Health Service national opt-out scheme, ensuring data privacy and ethical compliance.

Main Results:

  • The GCC database supports case-control studies and the investigation of factors associated with cancer diagnosis.
  • Approximately 8000 cancer diagnoses occur annually at Guy's Cancer Centre, contributing to the cohort.
  • The renewal and expansion of the GCC optimize data collection and linkage for research purposes.

Conclusions:

  • The Guy's Cancer Cohort database provides essential infrastructure for diverse cancer research questions.
  • Its ongoing development and expansion are crucial for advancing cancer research and improving patient outcomes.
  • Pseudonymised datasets are available for research applications via cancerdata@gstt.nhs.uk.