Related Experiment Video
Updated: Feb 7, 2026

Statistical Modelling of Cortical Connectivity Using Non-invasive Electroencephalograms
Published on: November 1, 2019
Frequency-resolved cortical functional connectivity across the adult lifespan
Santeri Ruuskanen1, Juan Camilo Avendano-Diaz1, Mia Liljeström1,2
1Department of Neuroscience and Biomedical Engineering, Aalto University, Espoo, Finland.
None:
The operation of the human brain relies on functional networks enabled by inter-areal oscillatory synchronization between neuronal populations. Although disruptions in this functional connectivity are associated with brain disorders, evidence on its healthy age-dependent variation and behavioral relevance remains limited. Utilizing magnetoencephalography (MEG) recordings from 576 adults aged 18-87 years, we investigated the evolution of resting-state functional connectivity (rs-FC) across the healthy adult lifespan. We observed age-related, frequency-specific changes in widespread cortical networks. Alpha-band (8-13 Hz) rs-FC decreased, while delta (1-4 Hz), theta (4-8 Hz), and gamma-band (40-90 Hz) rs-FC increased with age. Beta-band (13-30 Hz) rs-FC followed a non-linear trajectory, peaking in middle age. The global delta, theta, alpha, and beta-band patterns differed from concurrent changes in oscillatory power, underscoring their dissociable contributions. Notably, reduced beta-band rs-FC was associated with increased sensorimotor attenuation, indicating that changes in rs-FC are behaviorally relevant for sensorimotor function. These findings advance our understanding of healthy brain aging and highlight a link between resting-state brain activity and sensorimotor integration.
Related Concept Videos
Functions of Connective Tissues
Hard connective tissues, such as bones and cartilage, provide structure and support to the body.
Frequency-dependent Selection
Dietary Connections
Adult Stem Cells
Introduction to Connective Tissues
Classification of Connective Tissues
Connective Tissue Proper
Connective tissue proper is the most abundant class of connective tissues. As its name implies, it predominantly connects different tissues in the body. Depending on the cell types, ground substance, viscosity, and fiber types in the ECM, connective tissue proper is further categorized into loose and dense....

