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Updated: Feb 7, 2026
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Simultaneous Two-photon In Vivo Imaging of Synaptic Inputs and Postsynaptic Targets in the Mouse Retrosplenial Cortex
Published on: March 13, 2016
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State-Dependent Dissociation of Shared Input and Directed Information Flow in the Visual Cortex
Yuxuan Xue1,2, Mitchell Morton3, Anirvan S Nandy4,5,6,7
1Department of Electrical Engineering, Yale University, New Haven, CT 06510.
Biorxiv : the Preprint Server for Biology
|February 6, 2026
Summary
Brain state and sensory input distinctly shape communication between cortical layers. Visual input drives directional flow, while wakefulness promotes symmetric coordination, revealing distinct mechanisms of neural communication.
Area of Science:
- Neuroscience
- Computational Neuroscience
- Systems Neuroscience
Background:
- Interpreting cortical population dynamics requires understanding how brain states and sensory inputs influence inter-laminar communication.
- Neural communication patterns are crucial for information processing in the brain.
Purpose of the Study:
- To quantify the low-dimensional predictive subspaces linking input and superficial layers in macaque V1.
- To investigate how visual stimulation and internal brain state modulate these communication pathways.
Main Methods:
- Laminar recordings in macaque V1.
- Reduced-rank regression to identify predictive subspaces.
- Delay analysis and network simulations.
Main Results:
- Both visual stimulation and internal state (eyes open vs. closed) modulate communication subspaces.
- Visual input creates directional, feedforward communication; wakefulness enhances symmetric coordination.
- Differential structure across layers predicts communication asymmetry.
Conclusions:
- Communication pathways are shaped by distinct mechanisms of sensory input and internal brain state.
- Findings differentiate genuine information flow from global state dynamics in neural coupling.
- Provides a framework for interpreting inter-population correlations in broader cortical circuits.
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