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Updated: Feb 8, 2026

Signal Acquisition, Score Interpretation, and Economics of a Non-Invasive Point-of-Care Test for Coronary Artery Disease
06:16

Signal Acquisition, Score Interpretation, and Economics of a Non-Invasive Point-of-Care Test for Coronary Artery Disease

Published on: August 9, 2024

958

Causal relationships between psoriasis and coronary artery disease: A two-sample Mendelian randomization study

Yang Xu1, Juhua Zhao

  • 1Beijing Anzhen Nanchong Hospital of Capital Medical University & Nanchong Central Hospital, Nanchong, Sichuan, China.

Medicine
|February 6, 2026
PubMed

Insights

Psoriasis significantly increases the risk of developing coronary artery disease (CAD), including heart attacks and angina. However, coronary artery disease does not appear to cause psoriasis.

Area of Science:

  • Cardiovascular Medicine
  • Dermatology
  • Genetics

Background:

  • Psoriasis, a chronic inflammatory skin condition, has been linked to cardiovascular diseases.
  • The causal relationship between psoriasis and coronary artery disease (CAD) remains uncertain.

Purpose of the Study:

  • To investigate the causal link between psoriasis and CAD using Mendelian randomization.
  • To assess if CAD influences the incidence of psoriasis.

Main Methods:

  • Utilized genome-wide association studies (GWAS) data for psoriasis and CAD.
  • Employed Mendelian randomization (MR) analysis with the inverse-variance weighted (IVW) method.
  • Conducted reverse MR analyses to test for causality in the opposite direction.

Main Results:

  • Psoriasis is causally associated with an increased risk of CAD (OR=11.538, P<0.001).
  • Psoriasis is also linked to a higher risk of coronary heart disease (OR=1.080, P=0.001).
  • No evidence of a causal effect of CAD on psoriasis was found.

Conclusions:

  • This study provides strong evidence for a causal relationship between psoriasis and the incidence of CAD.
  • The findings suggest that psoriasis is a risk factor for developing cardiovascular disease.
  • There is no evidence of a reverse causal association from CAD to psoriasis.

Keywords:
Mendelian randomizationcoronary artery diseasepsoriasis

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