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Updated: Feb 8, 2026

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Computed Tomography (CT) Guided Implantation of a Totally Implantable Venous Access Port (TIVAP) through Subclavian Vein
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Evaluating Normal Saline Locking With Totally Implanted Vascular Access Devices for Patients on 90-Day Maintenance
Krystal Ramsey1, Jessika Ann Collins2, Brooke Toedte3
1Krystal Ramsey.
Clinical Journal of Oncology Nursing
|February 6, 2026
Summary
Normal saline alone is a safe alternative to heparin for flushing totally implanted vascular access devices (TIVADs). This study found no significant increase in partial occlusions when using normal saline for TIVAD maintenance flushing.
Area of Science:
- Vascular Access Device Management
- Evidence-Based Practice
- Clinical Nursing
Background:
- Heparin is a common locking solution for totally implanted vascular access devices (TIVADs).
- Limited data exist on using normal saline alone for TIVAD maintenance flushing over 90 days.
Purpose of the Study:
- To evaluate if using normal saline alone as a locking solution for TIVADs increases partial occlusions during a 90-day maintenance protocol.
Main Methods:
- A clinical team monitored alteplase administration to track partial occlusions.
- Nurses were educated on device maintenance, including pulsatile flushing and clamping techniques.
- Heparin use was deimplemented, transitioning to normal saline for TIVAD locking.
Main Results:
- A comparison was made between 2,908 encounters with heparin locking and 3,239 encounters with normal saline locking.
- Minimal variance in partial occlusions was observed between the two locking solutions.
Conclusions:
- Normal saline alone can be effectively used as a locking solution for TIVADs.
- The transition from heparin to normal saline did not result in a significant increase in device occlusions.
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