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Extracellular vesicles mediate stem cell signaling and systemic RNAi in planarians

Vidyanand Sasidharan1,2, Laura Ancellotti3, Viraj Doddihal4

  • 1Stowers Institute for Medical Research, Kansas City, MO, USA.

Science Advances
|February 6, 2026
PubMed
Summary

Planarian flatworms release abundant extracellular vesicles (EVs) that shuttle small RNAs, mediating systemic RNA interference (RNAi) and regulating regeneration. AGO-3 protein is crucial for this EV-based intercellular communication.

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