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Author Spotlight: Advancing Facial Rejuvenation Therapy with Post-Laser Salicylic Acid Application
Published on: September 27, 2024
Efficacy and Safety of Sodium Hyaluronate Gel for Facial Skin Rejuvenation
Zhifeng Liao1, Weijin Hong1, Shiliang Wang2
1Department of Plastic and Reconstructive Surgery, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou City, China.
Background:
Hyaluronic acid (HA) is a cornerstone of aesthetic skin treatments due to its vital role in skin hydration and combating aging signs.
Objective:
This trial evaluated the efficacy and safety of a novel non-cross-linked HA gel for improving skin quality in a Chinese population.
Materials And Methods:
In this multicenter, randomized, controlled trial, 420 subjects were enrolled (2:1, treatment: control). The treatment group received three full-face intradermal injections of the HA gel at 3-week intervals, whereas the control group received no intervention. Primary end points were blinded evaluations of the Global Aesthetic Improvement Scale and a composite improvement rate for skin dryness/dullness.
Results:
The treatment group showed significantly higher Global Aesthetic Improvement Scale improvement (90.63% vs 3.65%) and composite improvement rates (83.20% vs 3.65%) than control group ( p < .0001), with effects sustained for 6 months. Skin hydration and elasticity significantly increased from baseline ( p < .05). Peak efficacy rates for fine lines and roughness reached 51.59% and 50.00%, respectively. Adverse events were mild and transient, with decreasing incidence.
Conclusion:
This non-cross-linked HA gel effectively enhances skin hydration, elasticity, and texture with sustained 6-month benefits and a favorable safety profile, supporting its use for facial rejuvenation.
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