Long-Term Outcomes After Sepsis: Chronic Disease Management as a New Area of Focus?

Following a sepsis-related hospitalization, up to 50% of patients experience prolonged recovery and long-term effects. These effects can be physical, cognitive, or psychological and are sometimes termed Postsepsis Syndrome. This review outlines the current understanding of the long-term consequences of a sepsis, highlighting knowledge gaps especially in relation to the management of this syndrome and acquired multimorbidity. In addition, it describes potential future research opportunities and discusses how novel trial methodology could be utilized to ensure that patients are guided toward personalized care.