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Early Insights Into Maternal Antidepressant Use and the Human Infant Gut Microbiome
Katelyn Desorcy-Scherer1, Kerry McNamara1, Ryan Luellwitz2
1School of Nursing, University of Wisconsin-Madison, Madison, WI, USA.
Biological Research for Nursing
|February 7, 2026
Summary
Maternal selective serotonin reuptake inhibitor (SSRI) use may modestly alter the infant gut microbiome, particularly by week 4-6. Researchers observed changes in microbial diversity and specific bacterial genera with SSRI exposure.
Area of Science:
- Microbiology
- Developmental Pediatrics
- Pharmacology
Background:
- Maternal SSRI use is prevalent during pregnancy and lactation.
- Serotonin signaling impacts gut microbial composition.
- The infant gut microbiome is crucial for immune and metabolic development.
Purpose of the Study:
- To investigate the impact of maternal SSRI use on the infant gut microbiome.
- To assess changes in microbial diversity and composition in infants exposed to SSRIs.
Main Methods:
- Pilot study of 20 maternal/infant dyads (10 SSRI, 10 control).
- 16S rRNA sequencing of 36 infant stool samples at 1-2 and 4-6 weeks.
- Statistical analysis considering SSRI exposure, feeding patterns, and delivery mode.
Main Results:
- No association found between maternal SSRI use and infant alpha diversity.
- Potential shaping of beta diversity by week 4-6 (p=0.072).
- Increased genera: Gemella, Staphylococcus, Corynebacterium; Decreased genus: Lactobacillus.
Conclusions:
- Maternal SSRI exposure may have a modest influence on the infant gut microbiome.
- Further research using metagenomics is needed to assess functional and clinical impact.
- This pilot study informs future research on SSRI effects on infant microbial development.
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