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RBPscan: A quantitative in vivo tool for profiling RNA-binding protein interactions.

Dmitry A Kretov1, Owen Sanborn2, Thora McIsaac2

  • 1Department of Biochemistry and Cell Biology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA 02118, USA; Department of Molecular Biology, Medical Biochemistry, and Pathology, Faculty of Medicine, Université Laval, Québec, QC G1V 0A6, Canada; Oncology Division, CHU de Québec - Université Laval Research Center, Québec, QC G1J 0J9, Canada; Université Laval Cancer Research Center, Québec, QC G1J 0J9, Canada.

Molecular Cell
|February 7, 2026
PubMed
Summary

A new method, RBPscan, uses RNA editing to profile RNA-binding protein (RBP) interactions in vivo. This tool quantifies RBP binding strength and identifies binding motifs across species.

Keywords:
ADARRBP-binding specificityRBPsRNA editingRNA motif discoveryRNA-binding proteinsadenosine deaminase acting on RNAdose-response analysismassively parallel reporter assaysmicroRNAsprotein-RNA interactions

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