Related Experiment Video
Updated: Feb 9, 2026
10:33
Transplantation of Olfactory Ensheathing Cells to Evaluate Functional Recovery after Peripheral Nerve Injury
Published on: February 23, 2014
12.3K
Olfactory Bulb Volume and Function Recovery in Eosinophilic Chronic Rhinosinusitis
Keisuke Yamamoto1, Masaki Abukawa2, Tsuyoshi Okuni1
1Department of Otolaryngology-Head and Neck Surgery, Sapporo Medical University School of Medicine, Sapporo, Japan.
The Laryngoscope
|February 7, 2026
Summary
Olfactory bulb volume (OBV) increased after surgery for eosinophilic chronic rhinosinusitis (ECRS), correlating with improved smell identification. Longer odor duration and higher symptom scores predicted smaller OBV increases, suggesting structural changes relate to olfactory recovery.
Area of Science:
- Otolaryngology
- Neurology
- Radiology
Background:
- Eosinophilic chronic rhinosinusitis (ECRS) significantly impacts olfactory function.
- Olfactory bulb volume (OBV) changes may reflect disease severity and treatment response.
Purpose of the Study:
- To evaluate perioperative changes in OBV and olfactory function in ECRS patients.
- To assess the association between OBV changes and olfactory function using 3T MRI and olfactory tests.
Main Methods:
- Retrospective observational study of 32 ECRS patients undergoing functional endoscopic sinus surgery.
- Pre- and postoperative olfactory function assessed via multiple tests (Alinamin, T&T, OE, OSIT-J, VAS, SAOQ).
- OBV measured manually from 3T MRI FIESTA sequences; logistic regression used for analysis.
Main Results:
- Significant improvements observed in postoperative olfactory identification (OE, OSIT-J) and symptom scores (VAS, SAOQ).
- Mean OBV increased by 10.3% postoperatively (p=0.095).
- OBV change correlated with olfactory identification improvements (OE, OSIT-J); longer odor duration and higher SAOQ scores predicted smaller OBV increases.
Conclusions:
- 3T MRI with FIESTA provides a structural correlate for olfactory changes in ECRS.
- OBV changes correlate with postoperative olfactory identification, suggesting a link to functional recovery.
Related Concept Videos
02:41Constant Volume Calorimetry
30.8K
Calorimeters are useful to determine the heat released or absorbed by a chemical reaction. Coffee cup calorimeters are designed to operate at constant (atmospheric) pressure and are convenient to measure heat flow (or enthalpy change) accompanying processes that occur in solution at constant pressure. A different type of calorimeter that operates at constant volume, colloquially known as a bomb calorimeter, is used to measure the energy produced by reactions that yield large amounts of heat and...
30.8K
01:20Volume of Distribution
1.3K
The apparent volume of distribution (Vd) is a crucial pharmacokinetic parameter representing the hypothetical body fluid volume into which a drug disperses. It is calculated based on the total amount of drug in the body (estimated from the administered dose and bioavailability) divided by the plasma drug concentration. The total amount of drug in the body does not directly refer to the dose given but is derived by accounting for absorption, distribution, metabolism, and excretion processes.
1.3K
01:13Problem Solving: Volume
80
The volume of a fuel tank mounted on the wing of a jet aircraft can be modeled using the concept of solids of revolution. In this case, the tank is formed by rotating a two-dimensional region, defined by a mathematical function, about the x-axis. The region extends along the axis from zero to two meters, and the resulting three-dimensional shape is symmetric about the axis of rotation. Because the boundary curve lies directly against the axis, the disk method is an appropriate technique for...
80
01:15Respiratory Volumes
3.0K
Respiratory volumes are crucial metrics, meticulously measured to quantify the air exchanged in and out of the lungs during various phases of the breathing cycle. These precise measurements are vital for assessing lung function, diagnosing respiratory conditions, and monitoring overall respiratory health. Each parameter provides specific insights into the mechanics of breathing and the functional capacity of the lungs.
Tidal Volume (TV) Tidal volume (TV) is the air inhaled or exhaled in a...
Tidal Volume (TV) Tidal volume (TV) is the air inhaled or exhaled in a...
3.0K
01:17Work Done During Volume Change
5.2K
In mechanics, work is done on an object when the force acting on it displaces the object. In thermodynamics, work done on a system can be estimated when the system's volume changes during any thermodynamic process.
Consider a gas confined to a cylinder fitted with a movable piston at one end. If the gas expands from volume V1 to volume V2, it exerts a force on the piston, such that the piston moves by a distance dr.
The work done by the gas on the piston can be expressed as
Consider a gas confined to a cylinder fitted with a movable piston at one end. If the gas expands from volume V1 to volume V2, it exerts a force on the piston, such that the piston moves by a distance dr.
The work done by the gas on the piston can be expressed as
5.2K
01:24Muscle Recovery and Fatigue
4.2K
Muscle fatigue refers to the decline in a muscle's ability to maintain the force of contraction after prolonged activity. It primarily stems from changes within muscle fibers. Even before experiencing muscle fatigue, one may feel tired and have the urge to stop the activity. This response, known as central fatigue, occurs due to changes in the central nervous system, namely the brain and spinal cord. While there is no single mechanism that induces fatigue, it may serve as a protective...
4.2K