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Live-Streamed Exercise Intervention in Pregnant Women With MASLD (Live-MASLD): Protocol for a Randomized Controlled

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This study investigates a live-streamed exercise program for pregnant women with metabolic dysfunction-associated steatotic liver disease (MASLD). The intervention aims to improve maternal and infant health outcomes by reducing liver fat during pregnancy.

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Area of Science:

  • Obstetrics and Gynecology
  • Hepatology
  • Public Health

Background:

  • Metabolic dysfunction-associated steatotic liver disease (MASLD) in reproductive-aged women increases risks for gestational complications and adverse pregnancy outcomes.
  • Gestational MASLD can negatively impact the long-term health of offspring.
  • There is a need for effective interventions to manage MASLD during pregnancy.

Purpose of the Study:

  • To evaluate the efficacy of a live-streamed exercise intervention in pregnant women diagnosed with MASLD.
  • To assess the intervention's impact on MASLD progression and maternal-infant health outcomes.
  • To provide evidence for clinical management strategies for pregnant women with MASLD.

Main Methods:

  • A two-arm randomized controlled trial (Live-MASLD trial) involving pregnant individuals with MASLD in their first trimester.
  • Intervention group receives a supervised, live-streamed exercise program during the second and third trimesters.
  • Control group receives routine prenatal care; assessments at multiple time points including postpartum.

Main Results:

  • Primary outcome: between-group differences in changes to the hepatic steatosis index (LiSA) measured by visual transient elastography (ViTE).
  • Secondary outcomes include various maternal and infant health indicators.
  • Process evaluation for health economic assessment is included.

Conclusions:

  • The study will provide scientific evidence on the effectiveness of live-streamed exercise for gestational MASLD.
  • Findings will inform clinical guidelines for managing MASLD in pregnant populations.
  • The intervention has the potential to improve maternal-infant health trajectories.