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Updated: Feb 10, 2026

Detection of Invasive Pulmonary Aspergillosis in Haematological Malignancy Patients by using Lateral-flow Technology
Published on: March 22, 2012
Time to re-evaluate combination antifungal therapy for invasive aspergillosis and other invasive mycoses
Thomas S Harrison1, Thomas J Walsh2
1Institute of Infection and Immunity, and European Confederation of Medical Mycology Excellence Center, School of Health and Medical Sciences, City St George's University of London, UK; St Georges University Hospitals NHS Foundation Trust, London, UK; MRC Centre for Medical Mycology, and European Confederation of Medical Mycology Excellence Center, University of Exeter, UK.
Abstract:
Mortality from invasive aspergillosis remains unacceptably high, and the currently recommended treatment of triazoles is further challenged by rising resistance to these first-line agents. A previous randomised controlled trial of combination therapy with voriconazole plus anidulafungin versus voriconazole alone showed that the combination was safe and associated with a clinically significant reduction in all-cause mortality that, however, failed narrowly to meet conventional levels of significance. In this Personal View, we argue against a binary, negative interpretation of these results, and that the totality of the laboratory and clinical evidence favours a triazole-echinocandin combination for the treatment of immunocompromised patients with proven or probable invasive aspergillosis. Renewed efforts are needed to optimise and evaluate other combination approaches for aspergillosis and other life-threatening invasive fungal diseases as a means by which to mitigate antifungal resistance, maximise and prolong the utility of old and new agents, and drive down mortality.
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