Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Empirical Method to Interpret Standard Deviation01:09

Empirical Method to Interpret Standard Deviation

10.2K
The empirical rule, also known as the three-sigma rule, allows a statistician to interpret the standard deviation in a normally distributed dataset. The rule states that 68% of the data lies within one standard deviation from the mean, 95% lies within two standard deviations from the mean, and 99.7% lies within three standard deviations from the mean. Additionally, this rule is also called the 68-95-99.7 rule.
This rule is used widely in statistics to calculate the proportion of data values...
10.2K
Effects of EDTA on End-Point Detection Methods01:18

Effects of EDTA on End-Point Detection Methods

667
Different methods, such as visual observance of metal-ion indicators, spectroscopic techniques, and potentiometric methods, can determine the endpoint of an EDTA titration.
In the visual method, metal-ion indicators (metallochromic dyes), which have distinct colors in their free and complex forms, are added to the mixture to signal the titration's end point. They form stable complexes with metal ions, but these complexes are weaker than the corresponding metal–EDTA complexes. As a...
667
Calculating Standard Free Energy Changes02:49

Calculating Standard Free Energy Changes

25.6K
The free energy change for a reaction that occurs under the standard conditions of 1 bar pressure and at 298 K is called the standard free energy change. Since free energy is a state function, its value depends only on the conditions of the initial and final states of the system. A convenient and common approach to the calculation of free energy changes for physical and chemical reactions is by use of widely available compilations of standard state thermodynamic data. One method involves the...
25.6K
Standard Enthalpy of Formation02:37

Standard Enthalpy of Formation

49.3K
Enthalpy changes are typically tabulated for reactions in which both the reactants and products are at the same conditions. A standard state is a commonly accepted set of conditions used as a reference point for the determination of properties under other different conditions. For chemists, the IUPAC standard state refers to materials under a pressure of 1 bar and solutions at 1 M and does not specify a temperature. Many thermochemical tables list values with a standard state of 1 atm. Because...
49.3K
Standard Electrode Potentials03:02

Standard Electrode Potentials

50.4K
On comparing the reactivity of silver and lead, it is observed that the two ionic species, Ag+ (aq) and Pb2+ (aq), show a difference in their redox reactivity towards copper: the silver ion undergoes spontaneous reduction, while the lead ion does not. This relative redox activity can be easily quantified in electrochemical cells by a property called cell potential. This property is commonly known as cell voltage in electrochemistry, and it is a measure of the energy which accompanies the charge...
50.4K
Measurement: Standard Units03:38

Measurement: Standard Units

81.5K
Every measurement provides three kinds of information: the size or magnitude of the measurement (a number), a standard of comparison for the measurement (a unit), and an indication of the uncertainty of the measurement. While the number and unit are explicitly represented when a quantity is written, the uncertainty is an aspect of the errors in the measurement results.
81.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Standardization Challenges and Breakthroughs in Apolipoprotein B Detection: From Immunoassays to LC-MS/MS.

Mass spectrometry reviews·2026
Same author

Standardization Challenges in Glycated Albumin Measurement: Methodological Heterogeneity and Quantification Discrepancies.

Clinical chemistry·2026
Same author

A mutational signature for brain metastasis tropism in lung adenocarcinoma.

Discover oncology·2026
Same author

Multicenter comparison of three automated procalcitonin (PCT) assays and commutability evaluation of EQA/PT materials.

Clinica chimica acta; international journal of clinical chemistry·2026
Same author

Establishment of a candidate reference method and verification of reference intervals for serum copper in pregnant and non-pregnant women.

Annals of clinical biochemistry·2026
Same author

Hypoxia-Induced Osteopontin-Positive Glioma-Associated Macrophages Facilitate Glioma Mesenchymal Transition via NF-κB Pathway Activation.

Cancer communications (London, England)·2026

Related Experiment Video

Updated: Feb 10, 2026

Advanced Glycation End-Products Sensitize Human Sensory-Like Neuron Cells to Capsaicin-Induced Calcium Influx
06:05

Advanced Glycation End-Products Sensitize Human Sensory-Like Neuron Cells to Capsaicin-Induced Calcium Influx

Published on: May 2, 2025

1.1K

Glycated albumin: detection methods and standardization.

Rui Wu1, Tianjiao Zhang1, Chuanbao Zhang1

  • 1National Center for Clinical Laboratories, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital/National Center of Gerontology, PR China; Chinese Academy of Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, PR China.

Clinica Chimica Acta; International Journal of Clinical Chemistry
|February 8, 2026
PubMed
Summary
This summary is machine-generated.

Glycated albumin (GA) monitoring offers a 2-3 week glucose average, aiding diabetes management. Standardizing GA detection methods is crucial for accurate clinical results and improved patient care.

Keywords:
Detection methodsDiabetesGlycated albuminStandardization

More Related Videos

Standardized Method for Measuring Collection Efficiency from Wipe-sampling of Trace Explosives
07:22

Standardized Method for Measuring Collection Efficiency from Wipe-sampling of Trace Explosives

Published on: April 10, 2017

9.9K
A Standardized Method for Measurement of Elbow Kinesthesia
07:56

A Standardized Method for Measurement of Elbow Kinesthesia

Published on: October 10, 2020

7.9K

Related Experiment Videos

Last Updated: Feb 10, 2026

Advanced Glycation End-Products Sensitize Human Sensory-Like Neuron Cells to Capsaicin-Induced Calcium Influx
06:05

Advanced Glycation End-Products Sensitize Human Sensory-Like Neuron Cells to Capsaicin-Induced Calcium Influx

Published on: May 2, 2025

1.1K
Standardized Method for Measuring Collection Efficiency from Wipe-sampling of Trace Explosives
07:22

Standardized Method for Measuring Collection Efficiency from Wipe-sampling of Trace Explosives

Published on: April 10, 2017

9.9K
A Standardized Method for Measurement of Elbow Kinesthesia
07:56

A Standardized Method for Measurement of Elbow Kinesthesia

Published on: October 10, 2020

7.9K

Area of Science:

  • Clinical Chemistry
  • Biomedical Diagnostics
  • Analytical Chemistry

Background:

  • Diabetes mellitus requires consistent blood glucose monitoring for effective management.
  • Glycated albumin (GA) reflects average blood glucose over 2-3 weeks, complementing HbA1c for short-term monitoring and specific populations.
  • Current GA detection methods show significant variability, hindering clinical reliability.

Purpose of the Study:

  • To review the evolution of glycated albumin (GA) detection methodologies.
  • To analyze the current state and challenges in GA detection standardization.
  • To promote improved consistency and advancement in GA measurement techniques.

Main Methods:

  • Review of historical GA detection techniques (colorimetry, chromatography, immunoassays).
  • Focus on prevalent enzymatic assays used in automated biochemical analyzers.
  • Examination of standardized liquid chromatography-tandem mass spectrometry (LC-MS/MS) as a reference method.

Main Results:

  • Enzymatic methods are now standard clinical practice, replacing older techniques due to automation and ease of use.
  • A critical lack of standardized reference procedures causes inter-kit variability in GA assay results.
  • LC-MS/MS offers a standardized approach but requires further integration into routine clinical settings.

Conclusions:

  • Standardization of glycated albumin (GA) detection is essential for reliable clinical decision-making.
  • Addressing the variability in enzymatic assays is key to improving diagnostic accuracy.
  • Continued development and adoption of standardized methods like LC-MS/MS will advance diabetes care.