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Dietary Antioxidants and Cardiovascular Health: Insights from a 14-Year UK Biobank Trajectory Analysis

Ru Fu1, Tao Liu1, Ye Chen1

  • 1Department of Cardiology, The Third Xiangya Hospital, Central South University, Changsha, China.

Antioxidants & Redox Signaling
|February 8, 2026
PubMed

Insights

A high composite dietary antioxidant index (CDAI) is linked to lower risks of hypertension, cardiovascular diseases (CVDs), and death. Dietary adjustments to boost CDAI may aid CVD health management.

Area of Science:

  • Nutritional Science
  • Cardiovascular Medicine
  • Epidemiology

Background:

  • Hypertension (HT) and cardiovascular diseases (CVDs) are major global health concerns.
  • Dietary antioxidants play a crucial role in mitigating oxidative stress and inflammation.
  • The composite dietary antioxidant index (CDAI) integrates multiple antioxidant nutrients to reflect overall dietary antioxidant capacity.

Purpose of the Study:

  • To investigate the association between the CDAI and the progression of cardiovascular health.
  • To evaluate the impact of CDAI on the transition from hypertension to CVDs and subsequent mortality.
  • To explore the underlying mechanisms linking CDAI to reduced CVD risk.

Main Methods:

  • Prospective cohort study utilizing UK Biobank data (100,193 participants).
  • CDAI calculated based on intake of manganese, selenium, zinc, and vitamins A, C, and E.
  • Multivariable Cox regression and multistate models analyzed risks of HT, CVDs, mortality, and progression trajectories.

Main Results:

  • Higher CDAI quartiles were associated with significantly reduced risks of developing HT, CVDs, and all-cause mortality.
  • Elevated CDAI also lowered the risk of progression from HT to CVDs and from HT to death.
  • Mediation analysis suggested CDAI's protective effects are primarily direct, not solely mediated through hypertension reduction.

Conclusions:

  • The CDAI is a significant factor in managing cardiovascular disease progression.
  • Increasing dietary antioxidant intake to enhance CDAI may be a valuable strategy in CVD prevention and management.
  • Further research into dietary interventions targeting antioxidant capacity is warranted.
Abstract

Keywords:
all-cause mortalitycardiovascular diseasescomposite dietary antioxidant indexhypertensionprogression trajectory

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