Lactic Acid Bacteria-derived Bacteriocins: A Promising Antimicrobial Strategy against Multidrug-resistant for
Vijay Laxmi1, Sheetal Verma2, Manoj Kumar3
1Department of Microbiology, Faculty of Medicine, King George's Medical University, Lucknow, Uttar Pradesh, 226003, India.
Probiotics and Antimicrobial Proteins
|February 8, 2026
Summary
Lactic acid bacteria (LAB) derived bacteriocins show promise as novel antimicrobial agents against multidrug-resistant pathogens in neonatal sepsis. These microbial peptides offer a biocompatible, narrow-spectrum alternative to conventional antibiotics, potentially improving outcomes for newborns.
Area of Science:
- Microbiology
- Neonatal Medicine
- Antimicrobial Research
Background:
- Neonatal sepsis presents a significant global health challenge, exacerbated by rising multidrug-resistant (MDR) pathogens.
- Conventional antibiotics are losing efficacy against these resistant strains, necessitating alternative treatments.
Purpose of the Study:
- To review the antimicrobial activity, diversity, mechanisms, and clinical potential of lactic acid bacteria (LAB) derived bacteriocins.
- To explore bacteriocins from milk-derived microbiota for neonatal applications.
- To assess the suitability of microbial peptides for pharmaceutical use.
Main Methods:
- Literature review of in vitro studies on LAB-derived bacteriocins.
- Analysis of molecular diversity and mechanisms of action.
- Evaluation of physicochemical properties (stability, resistance, tolerance).
Main Results:
- LAB-derived bacteriocins demonstrate potent in vitro activity against MDR pathogens relevant to neonatal sepsis.
- These bacteriocins possess favorable physicochemical properties for pharmaceutical development.
- Bacteriocins from milk microbiota show particular promise for immunocompromised neonates.
Conclusions:
- LAB-derived bacteriocins represent a promising, biocompatible antimicrobial strategy complementary to existing antibiotics.
- Further clinical trials are essential to establish their efficacy and safety as adjunct or preventive therapies in neonatal intensive care units (NICUs).
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