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ProteoformDB: an integrative database for functional roles of proteoforms
Hanwen Luo1,2, Sichao Qiu1,2, Maozu Guo3
1School of Software, Shandong University, 1500 Shunhua Road, High-Tech Industrial Development Zone, Jinan, Shandong 250101, China.
Database : the Journal of Biological Databases and Curation
|February 9, 2026
Summary
ProteoDB is a new database integrating proteoform functions across species. It aids research into how molecular events drive functional differences in protein variants, advancing genomics and proteomics.
Area of Science:
- Genomics
- Proteomics
- Bioinformatics
Background:
- Proteoforms from alternative splicing expand cellular functions, contributing to genomic and proteomic diversity.
- Limited databases for proteoform functional annotations hinder research into their functional variations.
Purpose of the Study:
- Introduce ProteoformDB, a web resource for integrated proteoform functional annotations and analyses.
- Provide tools for predicting proteoform functions and understanding functional regulatory mechanisms.
Main Methods:
- Developed a web resource (ProteoformDB) with user-friendly interfaces for data search, visualization, and analysis.
- Integrated transcript-level functional annotations for proteoforms across multiple species.
- Enabled analysis of molecular events (sequence, domain, PTMs) impacting proteoform function.
Main Results:
- ProteoformDB organizes functional annotations for proteoforms from 214 animal and 28 plant species.
- The resource facilitates investigation into functional differences driven by molecular events.
- Includes data processing of 154.83 GB.
Conclusions:
- ProteoformDB serves as a valuable, expandable resource for proteoform function research.
- It supports studies in genome/transcriptome function, disease mechanisms, and related fields.
- Aids in uncovering functional differences between protein variants.
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