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Correlation between glycemic control and left ventricular diastolic dysfunction in type 2 diabetes

Aparnna Unnikrishnan Nair1, Sorabh Sharma2, Asma Aara Younus3

  • 1Department of Internal Medicine, Altnagelvin Hospital, Western Health and Social Care Trust, Londonderry, Northern Ireland, UK.

Bioinformation
|February 9, 2026
PubMed

Insights

Type 2 diabetes is linked to heart issues like diastolic dysfunction. Poorly controlled blood sugar (HbA1c) may worsen this cardiac dysfunction, highlighting the need for early screening in diabetic patients.

Area of Science:

  • Cardiology
  • Endocrinology
  • Diabetology

Background:

  • Type 2 diabetes mellitus (T2DM) is associated with increased cardiovascular morbidity.
  • Left ventricular diastolic dysfunction (LVDD) is a recognized complication in T2DM patients.
  • Glycemic control, measured by HbA1c, may influence the severity of cardiac dysfunction.

Purpose of the Study:

  • To investigate the relationship between HbA1c levels and LVDD in patients with T2DM.
  • To assess echocardiographic parameters indicative of diastolic dysfunction in relation to glycemic control.

Main Methods:

  • Echocardiographic measurements were used to evaluate diastolic function.
  • HbA1c levels were correlated with echocardiographic findings in T2DM patients.

Main Results:

  • A correlation was observed between higher HbA1c concentrations and the presence/severity of LVDD.
  • Poor glycemic control in T2DM patients is associated with echocardiographic evidence of diastolic dysfunction.

Conclusions:

  • HbA1c levels are a significant factor in the development of LVDD in T2DM.
  • Early cardiac screening and improved diabetes management are crucial for reducing cardiovascular morbidity in T2DM patients.

Keywords:
Type 2 diabetes mellitusdiastolic dysfunctionechocardiographyglycated hemoglobinleft ventricular function

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