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METS-VF outperforms traditional adiposity indices in predicting overactive bladder risk: a NHANES-based
Ping Cai1, Fu Feng2,3, Zhanping Xu2,3
1Division 3, Concord Medical Center, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences) Southern Medical University, Guangzhou, China.
Translational Andrology and Urology
|February 9, 2026
Summary
Visceral adiposity, measured by the metabolic score for visceral fat (METS-VF), is significantly linked to overactive bladder (OAB) risk. METS-VF shows greater predictive power for OAB than traditional obesity measures.
Area of Science:
- Urology
- Metabolic Health
- Public Health
Background:
- Overactive bladder (OAB) is a common urological condition with complex causes.
- The role of visceral adiposity in OAB pathogenesis is not well understood.
Purpose of the Study:
- To investigate the association between the metabolic score for visceral fat (METS-VF) and OAB risk in a US population.
- To compare the predictive utility of METS-VF against conventional adiposity indices for OAB.
Main Methods:
- Cross-sectional analysis of National Health and Nutrition Examination Survey (NHANES) data from 6,366 participants.
- Used multivariable logistic regression, subgroup analyses, and ROC analysis.
- Compared METS-VF predictive capabilities against BMI, WC, and WHtR.
Main Results:
- A significant link was found between METS-VF and OAB (P<0.001), with prevalence increasing across METS-VF quartiles.
- METS-VF remained significantly associated with OAB after full adjustment (OR=1.38, 95% CI: 1.22-1.57).
- METS-VF demonstrated superior predictive ability for OAB compared to BMI, WC, and WHtR.
Conclusions:
- METS-VF is a robust predictor of OAB risk in US adults.
- METS-VF's enhanced predictive capacity suggests potential for clinical risk assessment and public health strategies targeting visceral obesity.
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