Treatment of toxic epidermal necrosis lesions with ovine forestomach matrix

Stevens-Johnson syndrome and toxic epidermal necrosis (TEN) are used to describe a spectrum of acute mucocutaneous reactions primarily affecting the skin and mucous membranes, resulting in painful blisters and epidermal detachment. Swift diagnosis followed by management of the damaged epidermis is vital to prevent further infection, which if left untreated can become life-threatening. We report a case of TEN in a 42-year-old female who presented with 55% epidermal loss. Over the course of 41 days, the affected regions were treated with ovine forestomach matrix (OFM) grafts, which led to epithelial restoration of the lesions in 1-2 weeks with good functional and cosmetic outcomes. This case is the first documented use of OFM in the treatment of TEN lesions.