Related Experiment Video
Updated: Feb 10, 2026
09:35
Isolating Central Nervous System Tissues and Associated Meninges for the Downstream Analysis of Immune cells
Published on: May 19, 2020
10.9K
Mortality Predictors of Adult Meningeal Tuberculosis: Analysis from a Tertiary Center Using the Lancet Consensus
Pratiksha Kamboj1, Yogendra P Mathuria1, Pratima Gupta1
1Microbiology, All India Institute of Medical Sciences, Rishikesh, Rishikesh, IND.
Cureus
|February 9, 2026
Summary
Meningeal tuberculosis (TB) has a high fatality rate. Simple blood and cerebrospinal fluid (CSF) markers can predict mortality in patients with tuberculous meningitis (TBM), aiding early risk stratification and monitoring.
Area of Science:
- Neurology
- Infectious Diseases
- Public Health
Background:
- Meningeal tuberculosis (TB) presents a higher fatality rate compared to other central nervous system TB forms.
- Limited data exists on mortality predictors for tuberculous meningitis (TBM).
Purpose of the Study:
- To identify predictors of mortality in patients diagnosed with meningeal TBM.
Main Methods:
- An ambispective cohort study was conducted involving 132 adults with suspected meningitis.
- Patients were classified into definite, probable, or possible TBM groups using the Lancet Consensus criteria.
- Univariable and multivariable Cox proportional-hazards models were employed to determine mortality predictors.
Main Results:
- The overall in-hospital mortality rate for any form of TBM was 37.87%.
- Definitive TBM showed the highest mortality rate (32.3% of total deaths).
- Significant mortality predictors included fever, altered sensorium, elevated serum neutrophils, decreased serum lymphocytes, increased CSF lymphocytes, and decreased CSF neutrophils.
Conclusions:
- Hematological and cerebrospinal fluid (CSF) parameters serve as effective tools for risk stratification in TBM.
- These simple markers can guide early clinical decision-making and facilitate closer patient monitoring.
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