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Updated: Feb 10, 2026

Basic Research in Plasma Medicine - A Throughput Approach from Liquids to Cells
Published on: November 17, 2017
Analysis of the effects of plasma-generated active species on cells cultured in a microperfusion system
Hayata Okino1, Shinya Kumagai1
1Meijo University 1-501, Shiogamaguchi, Tempaku-ku Nagoya 468-8502 Japan skumagai@meijo-u.ac.jp.
Abstract:
Promoting cell growth is required in life science and medical applications. Thus far, microdevice researchers have been developing microperfusion systems for simulating in vivo conditions that are suited for cell growth. For advancing cell growth technology further, we applied plasma technology. Plasma is the fourth state of matter after solid, liquid, and gas. When plasma is generated under atmospheric conditions, it reacts with ambient air, producing reactive oxygen and nitrogen species (RONS), which affect cells. These RONS can be used as triggers for promoting cell growth. In this study, we achieved the delivery of RONS to the cells in a microperfusion system using simple methods. We evaluated plasma effects on cell growth and analyzed RONS propagation in a liquid medium for cells under microperfusion.
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