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Updated: Feb 10, 2026
Author Spotlight: Establishing an Accurate Microhardness Testing Protocol for Craniofacial Tissues
Published on: April 26, 2024
Comparative evaluation of the effect of intracanal medicaments calcium hydroxide, modified triple antibiotic paste,
Tanmayi D Thakur1, Kranthikumar Reddy1, B Rahul Deore1
1Department of Conservative Dentistry and Endodontics, ACPM Dental College and Hospital, Dhule, Maharashtra, India.
Aim:
The present study aimed to evaluate and compare the effects of three intracanal medicaments - calcium hydroxide (Ca(OH)2), modified triple antibiotic paste (MTAP), and Bio-C Temp - on the microhardness of root dentin.
Materials And Methods:
Twenty extracted mandibular premolars with single canals were decoronated and standardized to 14 mm length. Following biomechanical preparation using ProTaper rotary instruments, the specimens were randomly allocated into four groups: Ca(OH)2, MTAP, Bio-C Temp, and a control group without medicament. The medicaments were placed using a lentulospiral and the canals sealed. All samples were incubated at 37°C in 100% humidity for 14 days. Mid-root dentin discs of 2 mm thickness were obtained and microhardness was assessed using a Vickers hardness tester under a 200 g load for 15 s.
Statistical Analysis:
Data were analyzed using the Kruskal-Wallis test, followed by one-way ANOVA and Tukey's post hoc pairwise comparisons. The significance level was set at 5%.
Results:
MTAP produced the greatest reduction in dentin microhardness, followed by Ca(OH)2, while Bio-C Temp showed the least reduction. The control group exhibited the highest values. Differences among groups were statistically significant, except between Bio-C Temp and the control group.
Conclusion:
Bio-C Temp preserved dentin microhardness more effectively than Ca(OH)2 and MTAP, indicating its potential as a favorable intracanal medicament with minimal adverse structural effects.
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