Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

What is an Electrochemical Gradient?01:26

What is an Electrochemical Gradient?

128.4K
Adenosine triphosphate, or ATP, is considered the primary energy source in cells. However, energy can also be stored in the electrochemical gradient of an ion across the plasma membrane, which is determined by two factors: its chemical and electrical gradients.
The chemical gradient relies on differences in the abundance of a substance on the outside versus the inside of a cell and flows from areas of high to low ion concentration. In contrast, the electrical gradient revolves around an...
128.4K
Mechanism of Breathing I: Inspiration01:30

Mechanism of Breathing I: Inspiration

3.3K
Introduction to Inspiration: The Respiratory System in Action
The respiratory system, an essential network for breathing, comprises the conducting and respiratory zones, each playing a crucial role in the overall process of respiration. Let us explore the detailed mechanism of inspiration, or inhalation, which is the first phase of the respiratory cycle.
Pathway of Air during Inspiration
During inspiration, air enters our body through the nose or mouth and moves through the conducting zone,...
3.3K
Energy Line and Hydraulic Gradient Line01:27

Energy Line and Hydraulic Gradient Line

2.4K
Based on Bernoulli's equation, the energy line (EL) and hydraulic grade line (HGL) provide graphical representations of energy distribution in a fluid flow system. For steady, incompressible, inviscid flows, Bernoulli's equation is expressed as:
2.4K
Gradient and Del Operator01:14

Gradient and Del Operator

4.5K
In mathematics and physics, the gradient and del operator are fundamental concepts used to describe the behavior of functions and fields in space. The gradient is a mathematical operator that gives both the magnitude and direction of the maximum spatial rate of change. Consider a person standing on a mountain. The slope of the mountain at any given point is not defined unless it is quantified in a particular direction. For this reason, a "directional derivative" is defined, which is a vector...
4.5K
Dynamic Equilibrium02:20

Dynamic Equilibrium

63.1K
A reversible chemical reaction represents a chemical process that proceeds in both forward (left to right) and reverse (right to left) directions. When the rates of the forward and reverse reactions are equal, the concentrations of the reactant and product species remain constant over time and the system is at equilibrium. A special double arrow is used to emphasize the reversible nature of the reaction. The relative concentrations of reactants and products in equilibrium systems vary greatly;...
63.1K
Whole Body Regeneration01:33

Whole Body Regeneration

4.2K
Regeneration is the process of restoring injured or lost tissues, organs, or body parts. While simpler organisms generally show greater ability to regenerate their whole body, few complex animals show similarly exceptional regeneration. For example, planarian flatworms have a unique regenerative potential making them a popular study organism among biologists to understand the mechanisms of whole body regeneration. Other organisms, such as hydra, also show extreme regeneration potential;...
4.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

D-A Type Perylene Micelles With Synergistic Charge/Energy Transfer for Dual-Path ROS Generation and Enhanced Photocatalysis.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Effect of Vitamin C on bleeding and pain after kidney biopsy: a randomized controlled trial.

BMC medicine·2026
Same author

Interfacial Charge Transfer Governs Bias-Polarity-Selective Electroluminescence in van der Waals Tunneling Heterostructures.

Nano letters·2026
Same author

Multiscale structural connectome eigenmodes constrain human brain functional dynamics.

Communications biology·2026
Same author

Dual MOF-engineered 3D-printed alginate-based hydrogels for enhanced wound regeneration.

International journal of biological macromolecules·2026
Same author

Preparation of HMX/PMMA Composite Microspheres with Excellent Properties by Photoinitiated Emulsion Polymerization.

Molecules (Basel, Switzerland)·2026

Related Experiment Video

Updated: Feb 10, 2026

3D Printed Porous Cellulose Nanocomposite Hydrogel Scaffolds
06:36

3D Printed Porous Cellulose Nanocomposite Hydrogel Scaffolds

Published on: April 24, 2019

10.2K

A 3D-Printed Piezoelectric Scaffold With Bio-Inspired Gradient and Dynamic Adaptation for Tendon Regeneration.

Xinyue Huang1, Jiachen Liang1, Qing Jia1

  • 1Key Laboratory of Dental Maxillofacial Reconstruction and Biological Intelligence Manufacturing, School of Stomatology, Lanzhou University, Lanzhou, Gansu Province, P. R. China.

Advanced Materials (Deerfield Beach, Fla.)
|February 9, 2026
PubMed
Summary

This study introduces a novel piezoelectric hydrogel that dynamically adapts to tendon healing stages. The advanced scaffold promotes regeneration, reduces inflammation, and enhances biomechanical properties for effective tendinopathy treatment.

Keywords:
3D printingelectrical stimulationpiezoelectric scaffoldstendon regeneration

More Related Videos

Core/shell Printing Scaffolds For Tissue Engineering Of Tubular Structures
05:52

Core/shell Printing Scaffolds For Tissue Engineering Of Tubular Structures

Published on: September 27, 2019

10.0K
Novel Process for 3D Printing Decellularized Matrices
08:14

Novel Process for 3D Printing Decellularized Matrices

Published on: January 7, 2019

7.6K

Related Experiment Videos

Last Updated: Feb 10, 2026

3D Printed Porous Cellulose Nanocomposite Hydrogel Scaffolds
06:36

3D Printed Porous Cellulose Nanocomposite Hydrogel Scaffolds

Published on: April 24, 2019

10.2K
Core/shell Printing Scaffolds For Tissue Engineering Of Tubular Structures
05:52

Core/shell Printing Scaffolds For Tissue Engineering Of Tubular Structures

Published on: September 27, 2019

10.0K
Novel Process for 3D Printing Decellularized Matrices
08:14

Novel Process for 3D Printing Decellularized Matrices

Published on: January 7, 2019

7.6K

Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Regenerative Medicine

Background:

  • Tendon regeneration necessitates dynamic materials for support, adhesion prevention, and inflammation control.
  • Current strategies often lack adaptability to the complex healing process.

Purpose of the Study:

  • To develop and evaluate a novel, dynamically adaptive piezoelectric hydrogel for tendon regeneration.
  • To assess the hydrogel's ability to modulate the healing microenvironment and promote endogenous repair.

Main Methods:

  • Fabrication of a piezoelectric hydrogel with bioinspired anti-adhesive properties.
  • Incorporation of gradients in piezoelectricity, mechanical properties, and degradation rate.
  • In vitro and in vivo assessments of anti-inflammatory effects, macrophage polarization, bacterial inhibition, and tendon regeneration.

Main Results:

  • The hydrogel effectively reduced inflammation (downregulating TNF-α) and promoted M2 macrophage polarization.
  • Demonstrated inhibition of bacterial growth and stimulation of endogenous tendon regeneration, evidenced by increased collagen I deposition and improved fiber alignment.
  • Transcriptomic analysis revealed favorable modulation of mechanotransduction, tissue remodeling, and anti-inflammatory pathways, while downregulating fibrotic and oxidative stress markers.

Conclusions:

  • The dynamically adaptive piezoelectric hydrogel supports tendon healing by providing tunable mechanical and electrical stimulation and controlled degradation.
  • This multi-gradient scaffold shows significant potential as a therapeutic strategy for tendinopathy, promoting regeneration and improving biomechanical function.