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Updated: Feb 10, 2026

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Exploring the Role Of CD155 in Urothelial Carcinoma of the Urinary Bladder: An Immunohistochemical Study & Its

Passant Essam Shibel1, Aya Magdy Elyamany1, Galal El Shorbagy2

  • 1Department of Anatomic Pathology, Faculty of Medicine, Cairo University, Egypt.

Asian Pacific Journal of Cancer Prevention : APJCP
|February 9, 2026
PubMed
Abstract

Insights

Increased CD155 expression in bladder cancer correlates with advanced stage and PD-L1. This suggests CD155 may be a therapeutic target, potentially benefiting patients with combined blockade of CD155 and PD-L1 (programmed death-ligand 1).

Area of Science:

  • Oncology
  • Immunology
  • Urothelial Carcinoma Research

Background:

  • Urinary bladder carcinoma is highly immunogenic, with approved immune checkpoint inhibitors targeting PD-L1 (programmed death-ligand 1).
  • Novel immunotherapeutic targets are needed, as CD155 is an immune checkpoint molecule overexpressed in various cancers, linked to poor prognosis.

Purpose of the Study:

  • To evaluate CD155 expression in urothelial carcinoma of the urinary bladder.
  • To correlate CD155 expression with clinicopathological parameters and PD-L1 expression.

Main Methods:

  • Immunohistochemical staining for CD155 and PD-L1.
  • Analysis of 67 cases of urothelial carcinoma of the urinary bladder.

Main Results:

  • CD155 positivity was observed in 41.8% of cases, significantly associated with invasive tumors and advanced T stage.
  • PD-L1 positivity was observed in 35.8% of cases, associated with advanced T stage, metastasis, muscle invasion, and lymphovascular emboli.
  • A significant positive correlation was found between CD155 and PD-L1 expression.

Conclusions:

  • CD155 expression increases with advancing stage in urothelial carcinoma, indicating its potential as a therapeutic target.
  • The positive correlation between CD155 and PD-L1 suggests that combined blockade of both targets may benefit certain patients.
Keywords:
CD155PD-L1Urothelial carcinomaimmunohistochemistryurinary bladder

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