Prebiotics, Probiotics, and Postbiotics in Modulating Gut Microbiota: Emerging Therapeutic Approaches for Metabolic...

This review aims to discuss emerging therapeutic strategies for managing Metabolic Syndrome (MetS) by focusing on modulating the gut microbiota using prebiotics, probiotics, and postbiotics, emphasizing their mechanistic roles in restoring metabolic balance and improving host metabolic health.

The biotics exert various pharmacological effects in restoring gut health and managing MetS by modulating multiple gut-system axes, including the gut-brain axis, gut-liver axis, gut-immune axis, and gut-endocrine axis. Through these mechanisms, they influence satiety regulation, insulin sensitivity, bile acid metabolism, systemic inflammation, and overall energy homeostasis, thereby contributing in the management of MetS. This review categorizes therapeutic biotics into three distinct classes: Prebiotics, which serve as substrates to stimulate beneficial bacteria; Probiotics, which supplement the gut with live beneficial microorganisms; and Postbiotics, which are bioactive microbial byproducts that directly modulate host metabolism. Conventional therapies for MetS address individual conditions rather than the syndrome comprehensively, which can promote adverse drug reactions. Whereas, biotic interventions target gut microbiota, a central regulator of energy balance, metabolic signalling and systemic inflammation. By restoring microbial composition and function, these biotics can simultaneously improve insulin sensitivity, reduce inflammation, regulate appetite, and modulate lipid and bile acid metabolism. This multi-dimensional modulation offers biotics as a promising adjunct or complementary strategy, capable of addressing the underlying dysregulation in MetS and offering a more integrative and mechanistic approach to its prevention and management.