Related Experiment Video
Updated: Feb 11, 2026
Author Spotlight: Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration
Published on: May 26, 2023
Agreement between a new SS-OCT biometer and a SD-OCT/Placido topographer for anterior segment measurements
Chak Seng Lei1, Qinghao Meng, Qingyi Gao
1From the Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, China (Lei, Gao, Xiahou, Zhou, Huang); NHC Key Laboratory of Myopia of Myopia and Related Eye Diseases, Key Laboratory of Myopia and Related Eye Diseases, Chinese Academy of Medical Sciences, Shanghai, China (Lei, Gao, Xiahou, Zhou, Huang); Shanghai Research Center of Ophthalmology and Optometry, Shanghai, China (Lei, Gao, Xiahou, Zhou, Huang); Eye Hospital and School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, Zhejiang, China (Meng); School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai, China (Yang); IRCCS Bietti Foundation, Rome, Italy (Savini, Schiano-Lomoriello).
Purpose:
To evaluate the agreement of anterior segment biometric measurements between a new swept-source optical coherence tomography (SS-OCT) biometer (ZW-30) and a spectral-domain optical coherence tomography combined with Placido-disk topography (SD-OCT/Placido topographer, MS-39).
Setting:
Eye and ENT Hospital of Fudan University, Shanghai, China.
Design:
Prospective cross-sectional study.
Methods:
This prospective, cross-sectional study recruited 70 healthy eyes from 70 participants. Each eye underwent 3 consecutive scans with both ZW-30 and MS-39. Parameters analyzed included central corneal thickness (CCT), anterior chamber depth (ACD), lens thickness (LT), mean keratometry (Km), J 0 and J 45 astigmatism vector components, and corneal diameter (CD). Interdevice differences were evaluated using paired t tests, and Bland-Altman analysis with 95% limits of agreement (LoA) assessed the agreement.
Results:
Significant differences were observed in all parameters measured, except for J 0 . Bland-Altman analysis indicated high agreement for CCT (mean difference: 5.38 ± 3.67 μm; 95% LoA: -2.73 to 13.48 μm), ACD (-0.11 ± 0.03 mm; -0.18 to -0.03 mm), LT (-0.06 ± 0.05 mm; -0.17 to 0.05 mm), Km (0.07 ± 0.16 diopter [D]; -0.33 to 0.47 D), J 0 (0.02 ± 0.12 D; -0.31 to 0.27 D), and J 45 (-0.08 ± 0.09 D; -0.32 to 0.16 D). A larger discrepancy was observed for CD (0.48 ± 0.13 mm; 0.17 to 0.79 mm).
Conclusions:
The ZW-30 SS-OCT biometer and the MS-39 SD-OCT/Placido topographer demonstrated high agreement for most anterior segment parameters, indicating their interchangeability in clinical practice. However, caution is advised when using CD measurements interchangeably because of the observed systematic differences between devices.
More Related Videos
Related Concept Videos
01:29Topographic Surveying and Contours
01:29Plotting of Topographic Maps
01:26Muscles of the Anterior Neck
02:58Crystal Field Theory - Octahedral Complexes
To explain the observed behavior of transition metal complexes (such as colors), a model involving electrostatic interactions between the electrons from the ligands and the electrons in the unhybridized d orbitals of the central metal atom has been developed. This electrostatic model is crystal field theory (CFT). It helps to understand, interpret, and predict the colors, magnetic behavior, and some structures of coordination compounds of transition metals.
CFT focuses on...
02:46Uncertainty in Measurement: Reading Instruments
02:16Measures of Central Tendency