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Determination of the Photoisomerization Quantum Yield of a Hydrazone Photoswitch
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Hydrazones as Potential Antimelanoma Prototypes: A Systematic and Patent Review
Brendo Vinícius Santos Macêdo1, Esdras Santos Macedo2, Michely Correia Diniz3
1Postgraduate Program in Biosciences, Federal University of the São Francisco Valley - UNIVASF, Campus Petrolina Center, Pernambuco, Brazil.
Anti-Cancer Agents in Medicinal Chemistry
|February 10, 2026
Summary
Hydrazones show promising in vitro anti-melanoma activity, particularly N-acylhydrazones. Further research is needed to confirm their potential as anti-cancer agents due to a lack of in vivo studies and patent filings.
Area of Science:
- Medicinal Chemistry
- Oncology
- Drug Discovery
Background:
- Melanoma is a highly metastatic and multidrug-resistant cancer.
- Hydrazone compounds exhibit potential in inhibiting various neoplasms.
- Assessing hydrazones as anti-melanoma agents is crucial for developing new therapies.
Purpose of the Study:
- To systematically review literature on hydrazones' anti-melanoma potential.
- To analyze patents related to hydrazones in melanoma treatment.
- To evaluate hydrazones as prototype anti-melanoma agents.
Main Methods:
- Systematic literature search (PubMed, Web of Science, ScienceDirect, Scopus) from Jan 2019-Feb 2024.
- Inclusion of original English-language studies with experimental anti-melanoma evaluation (in vitro/in vivo).
- Patent search using IPC code A61P35/00 in ESPACENET, WIPO, LENS, Google Patents.
Main Results:
- 35 out of 1,072 records met eligibility criteria.
- All included studies reported in vitro anti-melanoma activity; no in vivo data.
- N-acylhydrazones were the most studied subclass (19 studies); 41 patent filings identified.
Conclusions:
- Hydrazones, especially N-acylhydrazones, demonstrate significant in vitro anti-melanoma activity and selectivity.
- Limited patent filings and lack of in vivo data present challenges.
- Further research is essential to validate hydrazones as a distinct class of antineoplastic agents.
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