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Association of Edentulism With Subsequent Biological Age: A Cohort Study
Yusuke Matsuyama1, Sakura Kiuchi1, Jun Aida1
1Department of Dental Public Health, Institute of Science Tokyo, Tokyo, Japan.
Journal of Clinical Periodontology
|February 10, 2026
Summary
Tooth loss (edentulism) is linked to faster biological ageing in older adults. Maintaining oral health may promote healthier ageing and reduce disease susceptibility.
Area of Science:
- Gerontology
- Oral Health
- Biomarkers of Ageing
Background:
- Biological ageing involves a decline in physiological functions, increasing disease risk.
- Edentulism, or toothlessness, is a significant oral health issue in aging populations.
- The relationship between edentulism and the rate of biological ageing requires further investigation.
Purpose of the Study:
- To investigate the longitudinal association between edentulism and biological ageing in English adults.
- To determine if tooth loss predicts accelerated biological ageing over time.
Main Methods:
- Utilized data from the English Longitudinal Study of Ageing (ELSA) across three biennial waves.
- Assessed edentulism and estimated biological age using the Klemera and Doubal method with multiple biomarkers.
- Employed linear regression, adjusting for baseline biological age and other confounders, to analyze the association.
Main Results:
- Individuals with edentulism showed a significantly greater biological age compared to those with remaining teeth.
- After controlling for confounding factors, edentulism was associated with an average increase of 0.82 years in biological age.
- This association remained significant, highlighting a longitudinal link between tooth loss and accelerated ageing.
Conclusions:
- Edentulism is longitudinally associated with advanced biological ageing.
- Preventing tooth loss and promoting oral health are potential strategies for healthy ageing.
- Interventions targeting oral health may contribute to reducing age-related physiological decline.
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