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Updated: Feb 11, 2026

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Investigation of Macrophage Polarization Using Bone Marrow Derived Macrophages
Published on: June 23, 2013
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Association Between Bone Microstructure Derived From CBCT and Marginal Bone Loss in a Platform-Switched Implant
Wenxi Dong1, Xinrui Lang2, Jie Xia1
1School of Stomatology, Zhejiang Chinese Medical University, Zhejiang, Hangzhou, China.
Clinical Implant Dentistry and Related Research
|February 10, 2026
Summary
Peri-implant bone volume fraction (BV/TV) may protect against long-term marginal bone loss (MBL) around dental implants. However, bone surface fraction (BS/BV) and trabecular separation (Tb.Sp) are risk factors for MBL.
Area of Science:
- Dental Implantology
- Oral and Maxillofacial Radiology
- Biomaterials Science
Background:
- Platform-switched subcrestal implants are widely used.
- Marginal bone loss (MBL) is a key factor in implant success.
- Cone-beam computed tomography (CBCT) offers detailed bone microstructure assessment.
Purpose of the Study:
- To investigate the association between CBCT-derived bone microstructure parameters and MBL.
- To evaluate these relationships over 1-8 years around platform-switched subcrestal implants.
Main Methods:
- Retrospective analysis of 142 implants in 100 patients.
- CBCT-derived bone microstructure parameters (BV/TV, BS/BV, Tb.Sp, etc.) measured.
- Marginal bone loss (MBL) assessed at baseline, 1-3 years, and 3-8 years post-loading.
- Generalized estimating equations (GEE) used for statistical analysis.
Main Results:
- No significant associations between bone microstructure and MBL at early follow-ups (T0, T1).
- At long-term follow-up (T2, 3-8 years), peri-implant BV/TV was protective against MBL (p=0.0125).
- Peri-implant BS/BV (p=0.0384) and Tb.Sp (p=0.0270) were significant risk factors for long-term MBL.
Conclusions:
- Peri-implant BV/TV, BS/BV, and Tb.Sp are critical predictors of long-term MBL.
- Cortical bone thickness has limited impact on MBL.
- CBCT-based bone microstructure analysis can aid MBL risk prediction and clinical management.
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