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Urinary Bladder01:23

Urinary Bladder

3.5K
The urinary bladder is a hollow, muscular sac that temporarily stores urine before it is expelled from the body. It can hold approximately 600 mL of urine prior to micturition. The bladder is retroperitoneal and located behind the pubic symphysis in the pelvic floor.
In males, the bladder is situated in front of the rectum, while in females, it is positioned anterior to the vagina and uterus. The bladder floor contains an inverted triangular area called the trigone, defined by the two ureteric...
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Data Reporting and Recording01:24

Data Reporting and Recording

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Reporting and recording are crucial in data documentation. The timely, thorough, and accurate documentation of facts is essential when recording patient data. Failure to record findings during an assessment or interpretation of a problem will result in loss of information and make the patient document unreliable. The reader is left with general impressions if the information is not specific. A recording is documenting data of the individual's health information in a traceable, secure, and...
5.5K
Gene Therapy00:59

Gene Therapy

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Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
27.7K
Types of Reports I: Hands-off Report01:25

Types of Reports I: Hands-off Report

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A hand-off report, also known as a change-of-shift report, is a crucial nursing process that ensures the smooth transition of patient care responsibilities between nursing staff.
Following are the key components and categories of hand-off reports:
Purpose and Process:
1.5K
Types of Reports II: Incident or Occurrence Report01:21

Types of Reports II: Incident or Occurrence Report

1.3K
An Incident or Occurrence Report in a healthcare setting is a crucial document used to record any unexpected occurrence that may or may not have affected a patient, employee, or visitor. Such reports are critical to improving patient safety and include all details leading up to and including the event.
Purposes:
In the healthcare industry, reports play a crucial role in documenting incidents within an agency. The primary objective of these reports is to ensure patient safety, uphold the...
1.3K
Anatomy of the Genitourinary System II: Bladder and Urethra01:19

Anatomy of the Genitourinary System II: Bladder and Urethra

1.7K
The lower urinary system consists of the urinary bladder and urethra, which are essential in storing and expelling urine from the body. Together with the internal and external sphincters, these structures work together to regulate urination effectively.Anatomy of the BladderThe urinary bladder is a muscular, stretchable organ behind the pubic bone and in front of the rectum. In females, the bladder is positioned anterior to the vagina and inferior to the uterus, while in males, it is located...
1.7K

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Related Experiment Video

Updated: Feb 11, 2026

Topical Airway Anesthesia for Awake-endoscopic Intubation Using the Spray-as-you-go Technique with High Oxygen Flow
05:43

Topical Airway Anesthesia for Awake-endoscopic Intubation Using the Spray-as-you-go Technique with High Oxygen Flow

Published on: January 13, 2017

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Endoscopic Topical Application (ETA) Therapy for Refractory Overactive Bladder: A First-in-Human Report.

Takuya Sadahira1,2, Masahiro Sugihara3, Yosuke Mitsui1,4

  • 1Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, JPN.

Cureus
|February 10, 2026
PubMed
Summary

Refractory overactive bladder (OAB) is challenging to treat. Endoscopic topical application (ETA) of botulinum toxin (BTX) to the bladder trigone offers a promising sensory-focused approach for patients with OAB.

Area of Science:

  • Urology
  • Neuroscience
Keywords:
bladder trigonebotulinum toxinendoscopic topical applicationnew drug delivery systemsrefractory overactive bladder

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  • Pharmacology
  • Background:

    • Refractory overactive bladder (OAB) presents a significant clinical challenge, with existing treatments like anticholinergics, β3-agonists, and intradetrusor botulinum toxin (BTX) offering limited efficacy for some patients.
    • Emerging research highlights the role of bladder sensory mechanisms, particularly in the trigone, in contributing to persistent urinary urgency and frequency.
    • Current intradetrusor BTX injections may not effectively target these superficial sensory pathways due to drug distribution primarily within the detrusor muscle.