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Related Concept Videos

Solution Equilibrium and Saturation01:59

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Related Experiment Video

Updated: Feb 11, 2026

Induction of Periodontitis via a Combination of Ligature and Lipopolysaccharide Injection in a Rat Model
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Causal Association Between Transferrin Saturation and Periodontitis: A Mendelian Randomization Study.

Jie Gao

    Oral Health & Preventive Dentistry
    |February 10, 2026
    PubMed
    Summary

    This study found a causal link between transferrin saturation and periodontitis. While iron deficiency anemia did not show a causal association, managing iron status may help prevent periodontal disease.

    Keywords:
    Mendelian randomizationiron deficiency anemiairon statusperiodontitistransferrin saturation

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    Area of Science:

    • Oral Health Research
    • Hematology
    • Genetic Epidemiology

    Background:

    • Periodontitis is a common inflammatory disease affecting the gums.
    • Iron deficiency anemia (IDA) and iron status may influence periodontitis development.
    • Mendelian randomization (MR) offers a robust method to investigate causal relationships.

    Purpose of the Study:

    • To investigate the potential causal association between iron deficiency anemia and iron status with periodontitis.
    • To utilize Mendelian randomization (MR) analysis for robust causal inference.

    Main Methods:

    • A two-sample MR study using large-scale genome-wide association study data.
    • Inverse variance weighted (IVW) analysis as the primary method, supplemented by weighted median, weighted mode, and MR-Egger regression.
    • Sensitivity analyses including Cochran's Q-test, MR-Egger regression, MR-PRESSO, and leave-one-out analysis to ensure result validity.

    Main Results:

    • A significant positive causal association was found between transferrin saturation and periodontitis (OR=1.23, p=0.002).
    • No significant causal associations were observed for iron deficiency anemia, serum iron, serum ferritin, or TIBC.
    • Sensitivity analyses confirmed the robustness of the findings and indicated no significant heterogeneity or horizontal pleiotropy.

    Conclusions:

    • Transferrin saturation, a marker of iron availability, is causally associated with periodontitis.
    • Genetic evidence suggests anemia's potential role in periodontitis etiology.
    • Monitoring and managing systemic iron status may be crucial for periodontal disease prevention and treatment.