Bioabsorbable Endovascular Adhesive Tape (BEAT) for Improving Vascular Regeneration

The drug-coated balloons (DCBs) provide a combination therapy of balloon angioplasty and anti-proliferative drug delivery to target lesions, thereby facilitating the appealing concept of leaving nothing behind. However, several studies have highlighted significant challenges posed by low drug transfer efficiency and immediate lumen loss due to elastic recoil. Herein, we propose a bioabsorbable endovascular adhesive tape (BEAT) platform that can realize robust adhesion and complete transfer after balloon inflation, enabling efficient endoluminal drug delivery while providing temporary radial support against elastic recoil. This BEAT coated balloon contains sprayable Janus coating layers of crosslinked drug-eluting polyelectrolyte complexes (PECs) and poly(thioctic acid) (PTA) adhesive layer. Notably, the poly (L-lysine-co-L-leucine)-poly (acrylic acid) PECs (PKL-PAA, KLA) exhibit exceptional anti-coagulation properties and selective endothelial cell adhesion behavior. Moreover, the hydrophobic interaction and photo-controllable crosslinking of KLA PECs enable flexible mechanical tunability (0.74-10.9 MPa), robust swelling resistance, and enzyme-responsive biodegradability, thus guaranteeing temporary mechanical reinforcement for blood vessels with efficient drug delivery. In a rat abdominal aorta injury model, this BEAT coated balloon demonstrates intact transfer with mechanical compliance to the vessel and effectively attenuates neointimal hyperplasia. This BEAT platform offers a promising perspective for the development of DCBs in vascular interventions.