Metal Element-Doped Prussian Blue Enhanced Chemodynamic Therapy and Imaging of Breast Cancer

Breast cancer, one of the most common malignant tumors among women, has long posed a serious threat to human health. As a cutting-edge tumor-specific therapeutic strategy, chemodynamic therapy (CDT) depends on in situ catalytic generation of the hydroxyl radical (^•OH) to induce cell apoptosis, gaining extensive attention among the preclinical cancer research field currently. However, this therapeutic strategy is still hindered by inadequate endogenous hydrogen peroxide (H₂O₂) supply and limited catalytic efficiency in vivo. Herein, transition metal-doped hollow mesoporous Prussian blue nanoparticles (M-HMPB NPs, M═Co, Mn, and Ni) are tailor-made to deliver glucose oxidase (GOx) for dual-enhanced CDT. In addition, there is a cascade performance between the catalase activity of HMPB and the glucose catalytic activity of as-loaded GOx, effectively alleviating the supply shortage of H₂O₂. Furthermore, the introduction of IR-808 endows the HMPB-based nanosystem with magnetic resonance and fluorescent dual-imaging performance, which is promising to realize the therapeutic visualization of breast cancer. Therefore, this work proffers an attempt centered on the optimization of CDT and the construction of an integrated theranostic nanoplatform.