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Representation, Access, and Inclusion in Clinical Trials: A Patient-Centered Perspective from the ASCPT 2025 Patient
Stephani L Stancil1,2, Ricki Fairley3, Latoya Bolds-Johnson3
1Department of Pediatrics, University of Missouri Kansas City School of Medicine, Kansas City, Missouri, USA.
Clinical Pharmacology and Therapeutics
|February 11, 2026
Summary
Clinical trial diversity remains a challenge, with underrepresentation of key populations hindering therapeutic innovation. Actionable insights from diverse stakeholders are crucial for achieving equitable patient participation in clinical research.
Area of Science:
- Clinical pharmacology
- Therapeutic innovation
- Health equity
Background:
- Clinical trials are vital for developing new treatments but frequently fail to represent diverse patient groups.
- Underrepresentation of women, minorities, and children persists despite targeted inclusion efforts.
- Equitable representation in clinical trials is critical for ensuring new therapies benefit all populations.
Purpose of the Study:
- To highlight the persistent issue of underrepresentation in clinical trials.
- To offer practical strategies for improving patient diversity in therapeutic research.
- To present perspectives from a multidisciplinary panel on enhancing clinical trial inclusivity.
Main Methods:
- A perspective piece informed by discussions at the American Society for Clinical Pharmacology and Therapeutics Patient Forum.
- Incorporated insights from patients, clinicians, researchers, and patient advocates.
- Focused on actionable strategies for equitable representation.
Main Results:
- Identified persistent gaps in the participation of key demographic groups in clinical trials.
- Gathered diverse stakeholder perspectives on barriers and facilitators to inclusion.
- Formulated actionable recommendations for improving representation.
Conclusions:
- Achieving equitable representation in clinical trials requires ongoing, multifaceted efforts.
- Collaboration among patients, clinicians, researchers, and advocates is essential for progress.
- Addressing underrepresentation maximizes the therapeutic impact and generalizability of clinical trial findings.
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