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Pancreatic Metastases from Urothelial Cancer.
Maria Kyrkasiadou1, Ioannis S Papanikolaou1, Ekaterini Politi2
12 Propaedeutic Dept of Internal Medicine, National & Kapodistrian University of Athens, Attikon University Hospital, Chaidari, Greece.
European Journal of Case Reports in Internal Medicine
|February 11, 2026
Summary
Metastatic urothelial carcinoma (UC) to the pancreas is rare but presents diagnostic challenges. Histological confirmation via endoscopic ultrasound-guided fine needle biopsy is crucial for diagnosis and management.
Area of Science:
- Oncology
- Gastroenterology
Background:
- Urothelial carcinoma (UC) is a common cancer.
- Pancreatic metastasis from UC is exceptionally rare.
- Pancreatic masses in UC patients pose diagnostic difficulties.
Purpose of the Study:
- To highlight the rarity and diagnostic challenges of pancreatic metastasis in urothelial carcinoma.
- To emphasize the importance of histological confirmation for diagnosis.
- To discuss the role of endoscopic ultrasound-guided fine needle biopsy (EUS-FNB) and multidisciplinary team involvement.
Main Methods:
- A case report of an elderly male with a history of UC presenting with a pancreatic mass.
- Diagnostic workup included imaging and EUS-FNB.
- Treatment involved chemotherapy and immunotherapy.
Main Results:
- EUS-FNB confirmed metastatic UC in the pancreatic mass.
- The patient experienced rapid disease progression despite treatment.
- The patient ultimately succumbed to the disease.
Conclusions:
- Pancreatic metastasis from UC, while uncommon, must be considered in UC patients with pancreatic masses.
- Histological confirmation via EUS-FNB is essential for accurate diagnosis.
- Individualized management and multidisciplinary team involvement are critical for optimal patient care.
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