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Development of Cancer Therapy-Related Cardiac Dysfunction Is Associated With Disease Progression in Breast Cancer.
Fumika Haga1, Masayoshi Oikawa1, Tetsuya Tani1
1Department of Cardiovascular Medicine, Fukushima Medical University Fukushima Japan.
Circulation Reports
|February 11, 2026
Summary
Cancer therapy-related cardiac dysfunction (CTRCD) impacts breast cancer survival. Early detection of CTRCD using cardiac troponin I (cTnI) is crucial for both cardiac protection and improved cancer prognosis.
Area of Science:
- Cardiology
- Oncology
- Cardio-oncology
Background:
- Cancer therapy-related cardiac dysfunction (CTRCD) is a known complication of breast cancer treatment.
- Early detection via cardiac biomarkers like cardiac troponin I (cTnI) is recommended, but its prognostic impact is unclear.
Purpose of the Study:
- To investigate the impact of CTRCD on cancer prognosis in breast cancer patients undergoing cardiotoxic therapies.
- To assess the relationship between CTRCD, cardiac function, and cancer progression.
Main Methods:
- Prospective observational study of 273 breast cancer patients receiving anthracycline and/or HER2-targeted therapy.
- Serial measurements of cTnI, BNP, and LVEF over 24 months.
- CTRCD defined by LVEF decline; categorized as mild, moderate, or severe.
Main Results:
- CTRCD occurred in 14.7% of patients.
- Mild CTRCD associated with greater LVEF reduction in patients with elevated cTnI.
- CTRCD was an independent predictor of cancer progression (HR 2.50, P=0.018).
Conclusions:
- CTRCD is associated with reduced progression-free survival in breast cancer patients.
- Early CTRCD detection is vital for cardiac management and cancer prognosis.
- Highlights the role of cardiac biomarkers in predicting cancer outcomes.
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