Related Experiment Video
Updated: Feb 12, 2026

Investigating the Alleviating Effects of Bacillus cereus Administration on Colitis through Gut Microbiota Modulation
Published on: July 27, 2022
Wild Prunus cerasifera Ehrh. Polyphenols Alleviate Hyperglycemia in Type 2 Diabetes Mellitus Mice via Modulating Gut
Xinpeng Cheng1, Xing Xie1, Shibo Luo2
1National R&D Center of Freshwater Fish Processing, College of Life Science Jiangxi Normal University Nanchang Jiangxi China.
Abstract:
Our previous work demonstrated that wild Prunus cerasifera Ehrh. possesses notable in vitro hypoglycemic activity. This study further evaluated the effects of wild Prunus cerasifera Ehrh. polyphenol extract (WPPE) on T2DM mice. WPPE treatment significantly lowered blood glucose, improved insulin resistance, and reduced hepatic oxidative stress and inflammation in T2DM mice. It could promote the production of short-chain fatty acids and regulate the relative abundance of T2DM-associated bacteria like Muribaculaceae and Odoribacter, and enhance hepatic glycogen synthesis through activation of the key gene involved in the PI3K/AKT/TBC1D4 pathway, resulting in hypoglycemic effect based on the gut-liver axis. These findings support WPPE as a promising dietary candidate for T2DM management.
Related Concept Videos
Diabetes Mellitus: Type 2 and Gestational
PI3K/mTOR/AKT Signaling Pathway
Diabetes Mellitus: Overview and Type I Subtype
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Pathophysiology of Diabetes
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
C4 Pathway and CAM
C4 Pathway
The C4 pathway is used by plants such as...
Diabetes: Management and Pharmacotherapy
Insulin remains the cornerstone of treatment for most patients with type 1 and many...

