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McCune-Albright Syndrome: A Case Series.
Vishal Agarwal1, Sambit Das1, Amogh S Chappalagavi1
1Endocrinology, Diabetes and Metabolism, Kalinga Institute of Medical Sciences, Bhubaneswar, IND.
Cureus
|February 11, 2026
Summary
McCune-Albright syndrome (MAS) is a rare genetic disorder caused by GNAS mutations. This case series highlights varied MAS presentations, emphasizing the need for early diagnosis and tailored management strategies.
Area of Science:
- Genetics and Molecular Biology
- Endocrinology
- Pediatrics
Background:
- McCune-Albright syndrome (MAS) is a rare genetic disorder resulting from postzygotic somatic mutations in the GNAS gene.
- This mutation leads to constitutive activation of the Gsα protein and ligand-independent signaling in Gs-coupled receptors.
- Key clinical features include polyostotic fibrous dysplasia, café-au-lait macules, and endocrine hyperfunction, such as gonadotropin-independent precocious puberty (GIPP).
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