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Changes in visual acuity and retinal microstructures following vitrectomy for lamellar macular hole
Hitoshi Goto1, Noriko Kubota2, Yosai Mori3
1Department of Ophthalmology, Nippon Medical School Tama-Nagayama Hospital, Tokyo, Japan.
Plos One
|February 11, 2026
Summary
Vitrectomy significantly improves visual acuity and reduces retinal cysts in patients with lamellar macular hole (LMH). Epiretinal proliferation and ellipsoid zone disruption are linked to poorer visual outcomes post-surgery.
Area of Science:
- Ophthalmology
- Retinal Surgery
- Optical Coherence Tomography
Background:
- Lamellar macular hole (LMH) is a condition affecting central vision.
- Understanding the impact of surgical intervention on LMH is crucial for patient outcomes.
Purpose of the Study:
- To evaluate visual outcomes and optical coherence tomography (OCT) findings after vitrectomy for LMH.
- To identify factors influencing postoperative visual acuity in LMH patients.
Main Methods:
- Retrospective analysis of 42 patients with LMH undergoing vitrectomy.
- Assessment of best-corrected visual acuity (BCVA) and OCT parameters (cysts, epiretinal proliferation, ellipsoid zone disruption) preoperatively and postoperatively at 6 months.
Main Results:
- Mean BCVA improved significantly from 0.36 to 0.15 (p < 0.001) at 6 months post-vitrectomy.
- Significant reduction in inner and outer retinal cysts observed postoperatively.
- Epiretinal proliferation and ellipsoid zone disruption correlated with worse BCVA.
Conclusions:
- Vitrectomy is effective in improving visual acuity and reducing intraretinal cysts in LMH patients within 6 months.
- Preoperative visual acuity, epiretinal proliferation, and ellipsoid zone disruption are key predictors of poor visual outcomes.
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