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Plant microbiome regulation for sustainable agriculture
Jingying Zhang1, Weidong Liu2, Binglei Wang1
1State Key Laboratory for Gene Function and Modulation Research, Peking-Tsinghua Center for Life Sciences, Peking-Tsinghua-NIBS Graduate Program, New Cornerstone Science Laboratory, School of Life Sciences, Peking University, Beijing 100871, China.
Abstract:
Plant-associated microbiomes are vital for sustainable agriculture, enhancing crop nutrient uptake, stress resistance, and yield while reducing agrochemical reliance. Microbial regulation, the targeted manipulation of these microbiomes, bridges microbial ecological potential and agricultural application. Currently, this regulation is categorized by whether microbial genomes are modified, encompassing two core strategies: external conditioning and internal engineering. External conditioning is a genome-unaltered approach that reshapes microbial communities via environmental cues, host traits, and agronomic practices, enabling rapid, low-regulatory tuning of microbiome function. In contrast, internal engineering alters microbial genomes via CRISPR-based tools, synthetic communities, and in situ editing to lock in stable beneficial traits for consistent field performance. Emerging technologies like AI-powered predictive models and advanced delivery systems support both strategies by boosting microbial regulation precision and scalability. Ultimately, microbial regulation optimizes plant-microbe interactions, expediting sustainable agricultural solutions to enhance climate resilience and global food security.
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