A study on biocompatibility and implant stability of 3D printed alumina/magnesium silicate composite ceramic bone
Ying Zhang1, Syed Mesum Raza Naqvi1, Lisheng Sun2
1College of Mechanical and Electrical Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing, 210016, China; Institute of Addictive Manufacturing (3D Printing), Nanjing University of Aeronautics and Astronautics, Nanjing, 210016, China.
Abstract:
To address the requirements of moderate strength, high osseointegration, and low bone damage for bone screws applied in non - weight - bearing sites such as ligament reconstruction and bone defect repair, this study designed and fabricated alumina - magnesium silicate (Al2O3/MgSiO3) composite ceramic bone screws using digital light processing (DLP) 3D printing technology. Mechanical compression test results showed that when the doping amount of magnesium silicate (MS) reached 15 wt% (MS15 group), the compressive strength was 222.9% higher than that of the pure alumina (MS0 group). In vitro mineralization experiments and cell experiments indicated that the MS15 group exhibited the most excellent performance in inducing mineralization and stimulating the proliferation and differentiation of osteoblasts. Results of simulated working condition tests showed that the failure torque of the ceramic bone screws reached 3.42 ± 0.42 N m, the pull-out force reached 428.47 ± 10.80 N. Finite element simulation results demonstrated that the shallow thread design effectively reduced stress concentration, verifying the rationality of the structural design. Based on the existing experimental investigations and finite element simulation results, the Al2O3/MgSiO3 composite ceramic bone screws fabricated in this study exhibit favorable performance adaptability and promising application prospects in non-weight-bearing site scenarios, in comparison with their metallic and polymeric counterparts.
Related Concept Videos
Screw: Problem Solving
To evaluate the...
Self-Locking Screw
A square-threaded screw jack carrying a load is considered self-locking if the screw retains its position even after the moment applied to it is removed.
Classifying Matter by Composition
According to its composition, the matter can be classified into two broad categories — pure substances and mixtures.
A pure substance is a form of matter that has a constant composition throughout with uniform properties. For example, any sample of sucrose has the same composition and same physical properties, such as melting point, color, and sweetness, regardless of the source from which it is isolated.
A mixture is composed of two or...
Frictional Forces on Screws
A jack with a square-threaded screw is a mechanical device used to lift heavy loads by applying a force at its handle. When the force is applied, the screw turns, raising the load. The screw can...
Nuclear Stability
To hold positively charged protons together...
RNA Stability


