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Updated: Feb 13, 2026

Development of a Benchtop Model for Evaluating the Compatibility of Wound Dressing Materials with Negative Pressure Wound Therapy Systems
Published on: May 2, 2025
Dextran-altered foaming bacterial cellulose with Botryocladia leptopoda extract in a wound-dressing application
Shin-Ping Lin1, Tsung-Kai Yi2, Yi-Feng Kao2
1School of Food Safety, Taipei Medical University, Taipei, 11042, Taiwan; Ph.D. Program in Drug Discovery and Development Industry, Taipei Medical University, 250 Wu-Hsing Street, Taipei, 11031, Taiwan; Research Center of Biomedical Device, Taipei Medical University, 250 Wu-Hsing Street, Taipei, 11031, Taiwan.
None:
In this study, we developed a dextran-modified foaming bacterial cellulose (FBC) hydrogel that utilized foam medium with dextran in situ. The resulting dextran/FBC hydrogel exhibited a high water content (92.3%-94.2%) and enhanced epithelial cell proliferation compared to unmodified FBC (79.1% vs. 68.4%). Furthermore, the combination of dextran/FBC with Botryocladia leptopoda extract (AE) further improved cell proliferation to 97.1%. In vivo wound-healing experiments in mice demonstrated that AE-loaded dextran/FBC achieved the most effective wound remodeling, with a normal epidermal thickness and regeneration of functional structures such as pores and hair follicles by day 12. This biomaterial can be directly produced from microbial biosynthesis with no post-modification. Its biodegradability, sustainable green production process, and great wound-remodeling capacity highlight its potential as a novel moist wound dressing.
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