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Preoperative Serotonin Antidepressants Are Associated With Increased Postoperative Complications Following
Aesthetic Surgery Journal
|February 11, 2026
Summary
Preoperative use of serotonergic antidepressants is linked to higher short-term complication risks, including readmission and bleeding, after rhinoplasty surgery. Long-term revision rates remained comparable between groups.
Area of Science:
- Plastic Surgery
- Psychiatry
- Pharmacology
Background:
- Rhinoplasty is a common cosmetic procedure.
- Patients often have anxiety and depression, treated with serotonergic antidepressants.
- Concerns exist regarding antidepressant use and surgical complications.
Purpose of the Study:
- To assess the association between preoperative serotonergic antidepressant use and rhinoplasty complications.
- To evaluate short-term and long-term postoperative outcomes.
Main Methods:
- Retrospective cohort analysis of patients undergoing rhinoplasty.
- Comparison of patients using serotonergic antidepressants versus those not using them.
- Propensity score matching (PSM) for balanced cohorts (4,917 patients each).
Main Results:
- Increased short-term risks (30-90 days) for readmission, opioid use, and bleeding/hematoma in the antidepressant group.
- These elevated risks persisted at 60 and 90 days post-surgery.
- No significant difference in long-term surgical revision rates after 1 year.
Conclusions:
- Serotonergic antidepressant use is associated with increased short-term postoperative complications after rhinoplasty.
- The findings highlight potential risks for patients on these medications undergoing nasal surgery.
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