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Area of Science:

  • Gerontology
  • Public Health
  • Epidemiology

Background:

  • Handgrip strength, gait speed, Five-Times-Sit-to-Stand Test (FTSST) performance, skeletal muscle mass, and calf circumference are vital health indicators.
  • These metrics are particularly important for diagnosing sarcopenia, a condition characterized by muscle loss.

Purpose of the Study:

  • To establish comprehensive reference (normative) values for key health indicators in the Asian population.
  • To pool individual participant data from national cohorts across Asia to achieve this.

Main Methods:

  • Pooled analysis of data from 20 national cohorts across 12 Asian countries.
  • Included community-dwelling individuals aged 20 years and older, harmonizing data by sex and 5-year age groups.
  • Calculated percentiles (5th-95th) for each outcome to establish Pan-Asian, regional, and country-specific reference values.

Main Results:

  • Analysis included over 277,000 participants for handgrip strength and over 13,000 for gait speed.
  • Established reference values showed significant variations across age groups, sexes, and Asian regions (East, South, Southeast, West Asia).
  • Males generally exhibited higher values for handgrip strength, gait speed, FTSST performance, skeletal muscle mass, and calf circumference compared to females.

Conclusions:

  • This study presents the most extensive set of reference values for these health indicators in the Asian population.
  • The findings highlight clear age, sex, and regional gradients in these important health metrics.
  • These reference values serve as a valuable resource for clinical practice, public health initiatives, and research in Asia.