[Exploring the links between perimenopause, menopause, and depression]

Area of Science:

• Reproductive Endocrinology
• Neuroscience
• Psychiatry

Background:

• Sex hormones significantly impact women's mental health.
• Perimenopause and menopause increase vulnerability to depression.

Purpose of the Study:

• To review clinical aspects of perimenopausal and menopausal depression.
• To explore underlying neurobiological mechanisms.
• To provide management recommendations.

Main Methods:

• Literature review of current knowledge.
• Analysis of clinical specificities.
• Examination of neurobiological factors.

Main Results:

• Perimenopausal and menopausal depression present unique clinical features.
• Hormonal fluctuations are linked to neurobiological changes affecting mood.
• Evidence-based management strategies are available.

Conclusions:

• Understanding hormonal influences is crucial for women's mental health.
• Integrating current knowledge improves care for menopausal depression.
• Targeted interventions can enhance treatment outcomes.