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  2. A Multi-scale Linear-time Encoder For Whole-slide Image Analysis.
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  2. A Multi-scale Linear-time Encoder For Whole-slide Image Analysis.

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A Multi-scale Linear-time Encoder for Whole-Slide Image Analysis.

Jagan Mohan Reddy Dwarampudi, Joshua Wong, Hien Van Nguyen

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    |February 12, 2026

    View abstract on PubMed

    Summary
    This summary is machine-generated.

    We developed MARBLE, a novel Mamba-based framework for whole-slide image analysis. This efficient method improves accuracy and generalization in multi-scale biomedical image tasks.

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    Area of Science:

    • Computational pathology
    • Artificial intelligence in medicine
    • Biomedical image analysis

    Background:

    • Whole-slide image (WSI) analysis is complex due to gigapixel sizes and multiple magnifications.
    • Existing multiple instance learning (MIL) methods often use single-scale analysis.
    • Transformer models face computational challenges with quadratic attention costs.

    Purpose of the Study:

    • Introduce MARBLE, a purely Mamba-based MIL framework for efficient WSI analysis.
    • Enable parallel processing of multiple magnification levels for integrated reasoning.
    • Provide a scalable and modular alternative to attention-based architectures.

    Main Methods:

    • Developed the Multi-scale Adaptive Recurrent Biomedical Linear-time Encoder (MARBLE).
  • Employed a Mamba-based state-space model for linear-time sequence modeling.
  • Implemented parallel processing of multiple WSI scales with coarse-to-fine reasoning.
  • Main Results:

    • MARBLE demonstrated significant performance improvements across five public datasets.
    • Achieved up to 6.9% increase in Area Under the Curve (AUC).
    • Showcased up to 20.3% improvement in accuracy and 2.3% in C-index.

    Conclusions:

    • MARBLE establishes a new standard for efficient and generalizable multi-scale WSI analysis.
    • The Mamba-based approach offers a scalable solution overcoming limitations of existing methods.
    • MARBLE effectively captures cross-scale dependencies with minimal parameter overhead.