Related Experiment Video
Updated: Feb 13, 2026
11:16
Correlative Light- and Electron Microscopy Using Quantum Dot Nanoparticles
Published on: August 7, 2016
10.2K
Atomically preserved MXene quantum dots as a redox-responsive nanoplatform for light-controlled bidirectional ROS
Dejia Hu1, Tianhao Xia1, Danyang Xiao1
1School of Material Science and Engineering, University of Science and Technology Beijing, Beijing, 100083, PR China.
Materials Today. Bio
|February 12, 2026
Summary
Structurally intact MXene quantum dots (MQDs) were synthesized for adaptive redox regulation. These MQDs show promise in wound healing and regenerative medicine by modulating the microenvironment.
Area of Science:
- Materials Science
- Biomedical Engineering
- Nanotechnology
Background:
- MXene quantum dots (MQDs) offer therapeutic potential due to redox properties and photoactivity.
- Synthetic challenges like metal leaching and degradation limit MQD translation.
- Developing stable MQDs is crucial for advanced therapeutic applications.
Purpose of the Study:
- To develop a synthesis strategy for structurally intact Ti2C MQDs.
- To investigate the redox properties and therapeutic potential of these novel MQDs.
- To evaluate MQDs in a diabetic wound healing model.
Main Methods:
- Sodium ascorbate-mediated coordination and reduction for hydrothermal synthesis.
- Characterization of MQD structure, crystallinity, and titanium retention.
- Evaluation of ROS generation/scavenging, antibacterial activity, cellular effects, and wound healing efficacy.
Main Results:
- Successfully synthesized structurally intact Ti2C MQDs with high crystallinity and titanium retention.
- MQDs exhibited visible-light-activated ROS generation and broad-spectrum ROS scavenging.
- MQDs reduced oxidative stress, inflammation, and promoted M2 macrophage polarization in vitro.
- A collagen-alginate microneedle patch (MQDs@Col-SA MN) accelerated diabetic wound healing by ~80%.
Conclusions:
- This study presents the first structurally preserved MQDs with adaptive redox regulation capabilities.
- The developed MQDs demonstrate significant potential for microenvironment modulation and regenerative medicine.
- MQDs@Col-SA MN offers a promising therapeutic strategy for accelerated wound healing.
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