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Updated: Feb 13, 2026

Author Spotlight: Advancing Research on Candida albicans Biofilm-Associated Prosthetic Joint Infections
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Periprosthetic Joint Infection Caused by Brucella: Four Case Reports and a Systematic Review of Literature

Shenghong Wang1,2,3, Xiaoyun Sheng1, Laiwei Guo1

  • 1Department of Orthopaedics, The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou, China.

Arthroplasty Today
|February 12, 2026
PubMed
Abstract

Insights

Brucella periprosthetic joint infection (PJI) diagnosis and treatment strategies were reviewed. Serological tests are key for diagnosis, with revision surgery for loose implants and antibiotics for stable ones, showing no recurrence.

Area of Science:

  • Infectious Diseases
  • Orthopedic Surgery
  • Microbiology

Background:

  • Periprosthetic joint infection (PJI) caused by Brucella species is rare, leading to diagnostic and therapeutic uncertainties.
  • A lack of established consensus exists for managing Brucella-induced PJI.
  • This review focuses on assessing diagnostic and treatment strategies for Brucella-induced PJI.

Purpose of the Study:

  • To evaluate diagnostic methods for Brucella-induced PJI.
  • To assess treatment strategies for Brucella-induced PJI.
  • To provide recommendations for managing Brucella-induced PJI.

Main Methods:

  • Systematic review and case series analysis of 61 patients with Brucella-related PJI.
  • Literature search across PubMed, Web of Science, Embase, and Chinese Biology Medicine database.
  • Extraction and analysis of data on demographics, diagnosis, treatment, and outcomes.

Main Results:

  • Serological antibody tests demonstrated a 100% positive rate in diagnosis.
  • Joint aspiration and blood cultures showed lower sensitivities (53.84% and 41.67%, respectively).
  • Treatment involved revision surgery for loose implants and antibiotics +/- debridement for stable implants, with no reported recurrence.

Conclusions:

  • Prioritize preoperative serological tests for diagnosing Brucella PJI.
  • Manage loose implants with revision surgery.
  • Consider antibiotics alone or with debridement for stable implants.
Keywords:
ArthroplastyBrucellaDiagnosisProsthesis-related infectionsTherapeutics

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